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RESEARCH
Molecular Biophysics
- Marie-Eve Aubin-Tam, Delft
Synthetic biological materials: from artificial cell membranes to biomimetic minerals and living materials.
Mechanical processes at the cell membrane
We design, develop and use biophysical assays to track dynamical cellular processes occurring at the cell membrane. We study artificial cell membranes as well as living (algal and bacterial) cells. Our interest is in the study of individual biomolecules, cells and membranes under external physical/chemical stimuli. This, in the hope of understanding the molecular mechanisms driving biological processes.Living materials and biomineralized composites
We use microorganisms to fabricate bio-based and/or living materials. Most living organisms use elements in their environment to fabricate composite materials. Due to their intricate and hierarchical structure, biocomposite materials present improved material properties when compared with their pure inorganic counterparts.For more information:http://aubintamlab.tudelft.nl
× - Bertus Beaumont, Delft
Biological evolution has produced nanoscopic structures and machines that perform an astonishing range of complex functions in the living cell. We seek to understand how they work, how they evolved and how they can be engineered.
Because the architecture of living systems is hierarchical, with function at one level emerging from interacting components at lower levels, we take a multi-level approach. Accordingly, our research strategy combines tools from microbiology, (bio)physics, experimental evolution and synthetic biology to explore the relevant mechanisms from the quantum level up to the level of molecules, cells, populations and ecosystems.
We are also interested in the evolution of ecological diversity and nanoparticle toxicity.
For further information: https://beaumontlab.wixsite.com/beaumont-lab/research
× - Greg Bokinsky, Delft
Bokinski Lab: We are curious to learn how bacteria work, and in figuring out ways to make bacteria (even more) useful. We have both fundamental and applied projects, and are always happy to pursue research in new and interesting directions.
For more information:https://sites.google.com/site/bokinskylab/
× - Pouyan Boukany, Delft
The Boukany research group focuses on fundamental and applied topics in soft living matter, with a major emphasis on controlling and understanding the dynamics and transport of DNA into living cells. To do this, we apply cutting-edge micro/nano-fluidic technologies to manipulate and control the DNA and biomolecules for both fundamental biophysical studies and applications, such as non-viral gene therapy, biosensing and cancer therapy. We will employ both experimental and theoretical approaches in our research to understand fundamental issues in a wide variety of applications ranging from micro/nanofluidics, DNA biophysics, molecular rheology to gene therapy.
For more information: Group website: http://cheme.nl/ppe/people/boukany.shtml and https://www.tudelft.nl/tnw/over-faculteit/afdelingen/chemical-engineering/scientific-staff/boukany-group/
× - Stan Brouns, Delft
My lab is interested in the interaction between microbes and bacteriophages. We study the mechanisms that bacteria use to protect themselves from infections including CRISPR, and explore the adaptations that viruses have evolved to avoid defence systems. We isolate and engineer bacteriophages for phage therapy applications.
For more information: https://www.brounslab.org/
× - Christophe Danelon, Delft
Our group is engaged in the long-term effort to build a synthetic cell using a bottom-up biology approach. The core architecture of our minimal cell model consists of a cell-free gene expression system (called PURE system) encapsulated inside a lipid vesicle compartment (called liposome). Using in-liposome synthesis of proteins from DNA templates, we aim to reconstitute four essential cellular modules:
- DNA replication
- Vesicle growth through lipid biosynthesis
- Liposome division
- Biogenesis of the transcription-translation machinery
Our lab is also interested in origins of life questions, particularly on the emergence of RNA protocell models and on the influence of space radiation on prebiotic self-assembly processes (EXOcube programme).
For further information: http://christophedanelonlab.tudelft.nl/
× - Cees Dekker, Delft
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Our research ranges from the biophysics of DNA to synthetic cells and beyond. Please have a look below at the spectrum of our current projects.
Chromatin structure
Using single-molecule optical and AFM imaging and force-spectroscopy techniques, we seek to unravel the mechanistic aspects of the structure and dynamics of chromosomes.
Bacterial biophysics and bottom up biology
Our group studies bacterial cell division and is aiming to constitute a ‘bottom up biology’ in synthetic cells that can autonomously divide. Our main interest lies in cell division, chromatin structure, and spatial control. We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks and this assess the fundamental role of spatial confinement at the molecular and cellular level.
Nanopores
Nanopores represent an elegant and versatile tool to measure single molecules. We research novel detection modes with solid-state nanopores as well as various ways to measure proteins with nanopores.
Diagnostics for neglected diseases
We develop point-of-care diagnostics test of neglected tropical diseases within resource-limited settings, based on Crspr/Cas9 detecting of pathogen’s DNA in body fluids.
For further information: https://ceesdekkerlab.nl/ - Nynke Dekker, Delft
We focus on understanding the key cellular process of nucleic acid replication from a biophysical perspective in viral, bacterial, and eukaryotic systems. We perform our studies both using purified components and inside living cells. To study in particular the dynamic aspects of replication, we make use of state-of-the-art biophysics that is highly integrated with biochemistry. Quantitative biologists, biochemists, and biophysicists interested in establishing a mechanistic understanding of replication are welcome to apply to our highly international laboratory.
For more information:http://nynkedekkerlab.tudelft.nl/
× - Martin Depken, Delft
The molecular environment is intrinsically noisy, crowded, and bustling with activity. Yet, there is a myriad of molecular machines inside each cell that perform precise tasks with amazing precision and under strongly varying conditions. Using physical modelling we seek to identify the various design principles employed by nature to achieve the robust biological functioning needed to sustain life. To this end we take a bottom-up approach and (i) study how a particular machine behaves on a microscopic scale with our experimental collaborators, and then use theoretical modelling (ii) to understand how such behaviour translates into a robust biological function.
For further information:https://sites.google.com/site/depkengroup/home
× - Marileen Dogterom, Delft
The assembly, force generation and organization of cytoskeletal polymers lies at the basis of many essential cellular processes. The research objective of this group is to gain a quantitative understanding of the physics behind these cytoskeleton-based processes. This is achieved through a combination of in vitro experiments in simplified physically and biochemically controlled microfabricated environments, theoretical modelling and, increasingly, experiments in living cells.
For more information: https://www.tudelft.nl/en/faculty-of-applied-sciences/about-faculty/departments/bionanoscience/research/research-labs/marileen-dogterom-lab/
× - Peter Gast, Leiden
Electronic Structure and Function by Electron Paramagnetic Resonance (EPR)
The Leiden Spin Group concentrates on the study of the electronic and geometric structure and the dynamics of (transient) paramagnetic molecules and centers in the condensed phase. Metal centers in bio-inorganic complexes and in proteins are being studied, spin-labeled proteins, organic radicals and triplet states, and defects in semi-conductor nano-particles. Spin-spin interactions of electrons are exploited, between spin labels and between a paramagnetic metal center and a spin label, as well as electron-nuclear hyperfine interactions.
Use is made of advanced EPR techniques, which largely concern in-house instrumental developments. The group is a pioneer of high-frequency EPR, with the first pulsed EPR spectrometer at 95 GHz (W-band) and the recent development of a continuous-wave and pulsed EPR spectrometer at 275 GHz (J-band). Both cw and pulsed EPR experiments are performed as well as Electron-Nuclear DOuble Resonance (ENDOR) experiments, from room temperature to liquid helium temperatures, on solutions, solids and crystals.As compared to the classical EPR frequency of 9 GHz (X-band), the application of higher microwave frequencies provides enhanced electron Zeeman resolution, enhanced absolute sensitivity, enhanced nuclear Zeeman resolution, the possibility to study nuclei with small magnetic moment by ENDOR, and the possibility to study paramagnetic centers with a substantial zero-field splitting. Even more important is the fact that the availability of higher frequencies allows a multi-frequency approach of a research question.
The EPR observables concern the g tensor, the dipolar- and exchange tensors, and the nuclear hyperfine and quadrupole tensors. These observables provide a fingerprint of the electronic wave function and distance information to determine structure. In addition, line shape analysis of EPR spectra enables the study of reorientation dynamics of molecules or spin-carrying groups.
When necessary, complementary techniques are being used: optical absorption and emission spectroscopy, optically detected magnetic resonance, and quantum-chemical calculations.For further information: https://www.physics.leidenuniv.nl/epr
× - Edgar Groenen, Leiden
Electronic Structure and Function by Electron Paramagnetic Resonance (EPR)
The Leiden Spin Group concentrates on the study of the electronic and geometric structure and the dynamics of (transient) paramagnetic molecules and centers in the condensed phase. Metal centers in bio-inorganic complexes and in proteins are being studied, spin-labeled proteins, organic radicals and triplet states, and defects in semi-conductor nano-particles. Spin-spin interactions of electrons are exploited, between spin labels and between a paramagnetic metal center and a spin label, as well as electron-nuclear hyperfine interactions.
Use is made of advanced EPR techniques, which largely concern in-house instrumental developments. The group is a pioneer of high-frequency EPR, with the first pulsed EPR spectrometer at 95 GHz (W-band) and the recent development of a continuous-wave and pulsed EPR spectrometer at 275 GHz (J-band). Both cw and pulsed EPR experiments are performed as well as Electron-Nuclear DOuble Resonance (ENDOR) experiments, from room temperature to liquid helium temperatures, on solutions, solids and crystals.
As compared to the classical EPR frequency of 9 GHz (X-band), the application of higher microwave frequencies provides enhanced electron Zeeman resolution, enhanced absolute sensitivity, enhanced nuclear Zeeman resolution, the possibility to study nuclei with small magnetic moment by ENDOR, and the possibility to study paramagnetic centers with a substantial zero-field splitting. Even more important is the fact that the availability of higher frequencies allows a multi-frequency approach of a research question.
The EPR observables concern the g tensor, the dipolar- and exchange tensors, and the nuclear hyperfine and quadrupole tensors. These observables provide a fingerprint of the electronic wave function and distance information to determine structure. In addition, line shape analysis of EPR spectra enables the study of reorientation dynamics of molecules or spin-carrying groups.
When necessary, complementary techniques are being used: optical absorption and emission spectroscopy, optically detected magnetic resonance, and quantum-chemical calculations.For further information: https://www.physics.leidenuniv.nl/epr
× - Martina Huber, Leiden
Electronic Structure and Function by Electron Paramagnetic Resonance (EPR)
The Leiden Spin Group concentrates on the study of the electronic and geometric structure and the dynamics of (transient) paramagnetic molecules and centers in the condensed phase. Metal centers in bio-inorganic complexes and in proteins are being studied, spin-labeled proteins, organic radicals and triplet states, and defects in semi-conductor nano-particles. Spin-spin interactions of electrons are exploited, between spin labels and between a paramagnetic metal center and a spin label, as well as electron-nuclear hyperfine interactions.
Use is made of advanced EPR techniques, which largely concern in-house instrumental developments. The group is a pioneer of high-frequency EPR, with the first pulsed EPR spectrometer at 95 GHz (W-band) and the recent development of a continuous-wave and pulsed EPR spectrometer at 275 GHz (J-band). Both cw and pulsed EPR experiments are performed as well as Electron-Nuclear DOuble Resonance (ENDOR) experiments, from room temperature to liquid helium temperatures, on solutions, solids and crystals.As compared to the classical EPR frequency of 9 GHz (X-band), the application of higher microwave frequencies provides enhanced electron Zeeman resolution, enhanced absolute sensitivity, enhanced nuclear Zeeman resolution, the possibility to study nuclei with small magnetic moment by ENDOR, and the possibility to study paramagnetic centers with a substantial zero-field splitting. Even more important is the fact that the availability of higher frequencies allows a multi-frequency approach of a research question.
The EPR observables concern the g tensor, the dipolar- and exchange tensors, and the nuclear hyperfine and quadrupole tensors. These observables provide a fingerprint of the electronic wave function and distance information to determine structure. In addition, line shape analysis of EPR spectra enables the study of reorientation dynamics of molecules or spin-carrying groups.
When necessary, complementary techniques are being used: optical absorption and emission spectroscopy, optically detected magnetic resonance, and quantum-chemical calculations.For further information:https://www.physics.leidenuniv.nl/epr
× - Timon Idema, Delft
We are a (mostly) theoretical biophysics group that has the good fortune to be part of a large department housing both experimentalists and theorists. Our main research interest is the topic of collective dynamics, from the level of single molecules such as proteins and molecular motors, all the way up to cells in tissue and colonies of bacteria. In particular, we are currently working on the effects of membrane mediated interactions, mechanical interactions between cells in developing embryos, and collective dynamics of finite-size, self-propelled particles. On all these, we cultivate active collaborations with theoretical and experimental groups, both inside and outside our own department.
The theme that best captures the various research projects in our group is the study of collective dynamics phenomena in living systems, ranging from the interactions of many proteins at the nanoscale to many organisms at the population level. We predominantly use theoretical models and simulations to study these systems, though always in close collaboration with experimental groups. At present, we pursue three active lines of research: collective dynamics of self-propelled particles, collective dynamics of membrane-embedded proteins through membrane-mediated interactions, and the role of mechanics in early embryo development.
× - Arjen Jakobi, Delft
Our lab aims at a quantitative understanding of how biomolecular machines function in their native biological environment. Our approach is inspired by the idea that once we understand biology at the atomic level, then it becomes tractable by the laws and principles of chemistry and physics. Biological macromolecules adopt intricate three-dimensional arrangments that are critical to their function. We study these structures by making use of the high-resolution imaging tools of structural biology: electron cryo-microscopy (cryo-EM), correlative fluorescence and electron tomography (cryo-CLEM,) and macromolecular diffraction. Since both the physical dimension and the operation level of the systems we study are at the nanoscale, we collectively describe this as biomolecular nanoscopy.
More specifically, we are interested in the molecular machinery that individual cells employ to defend themselves against infection. Our research interests include the structure and function of host factors in intracellular immunity, the mechanism of force generation by large macromolecular assemblies on membranes and the role of autophagy in pathogen elimination. We combine cryo-EM with other structural methods to visualize the macromolecular complexes involved in these processes, and apply quantitative biochemical and biophysical tools to dissect their mechanism of action. The challenges implicit to this endeavour also lead us to develop, optimize and apply new approaches for cryo-EM sample preparation, imaging, image processing and data interpretation.For more information: http://jakobilab.tudelft.nl/home/
× - Chirlmin Joo, Delft
"The Joo group makes nanobiology tools to address important biological questions related to human beings.
Developing single-molecule protein sequencing techniques
Proteins are vital in all biological systems as they are the working machineries of cells. There are >20,000 protein species inside human cells which are expressed at all different levels. Medical scientists read the amino acid sequences of proteins to analyze the protein expression profiles of human cells; and biologists to chart protein‐protein interaction maps. Complete mapping, however, has not been achieved since current sequencing techniques have intrinsic limitations. We aim to develop several single-molecule sequencing techniques in response to urgent demand for a new large-scale, highly sensitive, error-free method.
Harnessing the genome editing ability of bacterial for genome editing
Genome editing is an essential tool for life sciences. Breakthroughs in 2012-2013 drew our attention to the genome editing ability of bacteria. We aim to understand this remarkable feature and to harness it for applications in science, technology, and society.
Repurposing the DNA elimination process for genome editing
CRISPR has revolutionized the way of editing a genome. Despite its wide use, CRISPR-genome editing has limitations, especially in the use for medical applications. Numerous studies have shown that
it suffers from the off-target effect. Its use is also restricted by its particular sequence requirement and its poor accessibility to a structured genome. Furthermore, recent studies suggested that it might act as a virulence factor within human cells.These limitations demand new genome editing tools. We aim to understand the molecular mechanism of Tetrahymena DNA elimination.For further information: http://www.chirlmin.org/
× - Gijsje Koenderink, Delft
Our lab is fascinated by the material properties of the biological soft matter that shapes our bodies: living cells and tissues. Living matter comprises viscoelastic materials with some resemblance to man-made soft materials such as polymer gels. However, they are unique in their ability to actively generate forces and change shape. We aim to understand the physical mechanisms that underlie this striking active mechanical behavior. We approach this challenge by combining concepts and techniques from soft matter physics, biophysics, bottom-up synthetic biology, protein engineering, and mechanobiology. We furthermore develop advanced measurement techniques that combine quantitative imaging with force measurements across length scales ranging from the cell/tissue level down to molecular scales.
For further information: https://www.tudelft.nl/en/faculty-of-applied-sciences/about-faculty/departments/bionanoscience/research/research-labs/koenderink-lab/
× - Liedewij Laan, Delft
Evolutionary Cell Biophysics
How is it possible that life is simultaneously highly robust on cell cycle timescales, yet also adaptable on evolutionary timescales? How do these properties emerge from the molecular building blocks of life? As pioneers of the emerging field of evolutionary cell biophysics, we are fascinated by how the physical and chemical properties of the building blocks, or components, of a cell (such as proteins, DNA, lipids etc. that need to obey physical and chemical laws) constrain and facilitate evolution of cellular functions. In this case a cellular function is the result of a complex, highly spatially and temporally regulated network, consisting of many different interacting components, “a biomolecular network”. The biomolecular network we focus on is symmetry breaking in budding yeast, which is the first step in polarity establishment and essential for proliferation. In budding yeast symmetry breaking is achieved by a biomolecular network of ~30 components which, through several regulatory feedback loops, form a localized protein pattern on the cell membrane. As a community we are starting to obtain a molecular understanding of how a living cell is organised by biomolecular networks on cell cycle timescales, however, how these networks reorganize over evolutionary timescales is still a major open question.Research Interests
How robust are functional networks to genetic perturbations? On short timescales, like a cell cycle, cells need be robust to perturbations (elastic), however on long evolutionary timescales mutations may allow cells to respond to adapt to their environment (plastic). So how hard is it to generate a new functional module that subsequently is robust to genetic perturbations on short time scales? Does redundancy in network functions allow cells to be more robust to perturbations? And what are the underlying molecular mechanisms that are responsible for the network changes?
For further information:http://laanlab.tudelft.nl/index.html
× - Dimphna Meijer, Delft
The group investigates the development of the central nervous system. We use molecular and cellular techniques to discover the mechanisms of neural diversity and neural circuitry formation. We specialize in cell-fate choice, neuronal partnering and the tripartite synapse.
For more information: https://www.tudelft.nl/tnw/over-faculteit/afdelingen/bionanoscience/research/research-labs/dimphna-meijer-lab/
× - John van Noort, Leiden
Chromatin is the ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotes. Packaging and depackaging of such chromatin, called chromatin remodeling, plays a central role in all cellular processes that involve chromosomes such as transcription,
replication, recombination, repair etc. The physical mechanisms governing these processes however, are still largely unknown. In our group we develop and use modern biophysical techniques to unravel the physics behind DNA condensation down to the single-molecule level.For more information: https://www.physics.leidenuniv.nl/vannoort
× - Tjerk Oosterkamp, Leiden
We explore the possibilities to combine magnetic resonance techniques with atomic force microscopy together in a single microscope: the MRI-AFM, also called Magnetic Resonance Force Microscopy (MRFM).
Video: http://fastfacts.nl/en/content/tjerk-oosterkamp-feeling-proteins
For further information: https://www.physics.leidenuniv.nl//oosterkamp
× - Michel Orrit, Leiden
We are interested in the far-field optical detection and spectroscopy of individual molecules and metal nanoparticles. These nano-objects can be studied for themselves or can report on their nearby surroundings, for example in biological environments. We are currently working on single gold nanoparticles (nanospheres, nanorods) and on single organic molecules in liquids or on solid substrates, at ambient conditions or at liquid-helium temperatures. Our projects are related to quantum optics, plasmonics, soft matter physics, biophysics, and generally physical chemistry.
For more information: https://www.single-molecule.nl/
× - Thomas Schmidt, Leiden
The way how cells can reliably and fast react on the outside world is a fascinating puzzle which drives research in my group. Most of the communication of the cell with its environment is taking place at the cellular membrane. By novel technological tools developed in my group together with theoretical modeling we try to shed a bit of light into so-far unexplored fields of biological research.
For further information: https://schmidtlab.physics.leidenuniv.nl/
× - Stefan Semrau, Leiden
We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types. Using single-cell transcriptomics and single-molecule microscopy in combination with machine learning and mathematical modeling we seek to unravel the dynamics of the decision making process and understand the interplay of internal factors (epigenetics, cell cycle, stochastic gene expression) and external factors (signaling molecules, cell-cell contacts, mechanical cues). We believe that the basic principles discovered through our research will be of great value for applications in regenerative medicine and the eradication of cancer stem cells.
For further information: http://www.semraulab.com/
× - Sander Tans, Delft
We study the dynamics of singel proteins and cells using novel experimental approaches
At the molecular level, we use optical tweezers and single-molecule fluorescence to reveal how chaperones are able to fold amino-acid chains into functional proteins, and prevent protein-malfunction diseases.
Our laboratory is interested in single-molecule protein folding, gene expression dynamics and evolutionary dynamics.
× - Claire Wyman, Delft
We aim to understand fundamental principles that determine complex biological processes. We currently focus on the process of double-strand DNA break repair in relation to genomic (in)stability, carcinogenesis and radio- and chemotherapy. We develop and apply new methods from single molecule imaging to live cell microscopy for quantitative analysis of detailed molecular function. Although our focus is fundamental knowledge, the mechanistic information we reveal are needed both to understand molecular causes that promote tumor formation, and to design of strategies specifically sensitizing rapidly dividing cells to anti-cancer treatments based on DSB induction.
For more information: https://www.erasmusmc.nl/en/research/researchers/wyman-claire
× - Hyun Youk, Delft
Our lab aims to understand how living systems bidirectionally transition between being alive and being either truly dead or seemingly dead. We try to identify all the ways in which these transitions can occur. By doing so, we hope to discover common, quantitative principles that underlie them. We are particularly eager to unveil principles that allow life to be restarted after it has nearly/completely ceased. Our studies use microbes and mammalian cells (e.g., yeasts and mouse embryonic stem cells). We combine experiments, mathematical models, and ideas rooted in statistical physics to achieve our goal.
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For more information: visit the Youk Lab website. - Kristin Grussmayer, Delft
Biophysics and Microscopy to Understand Life at the Nanoscale
Our goal is to develop advanced 3D light microscopy methods to perform quantitative studies in live cells to answer fundamental questions in molecular and cell biology. We combine label-free and molecule-specific super-resolution fluorescence readouts to assess mechanical properties, dynamics and structure.
Our interdisciplinary Bionanoscience group builds upon synergies from molecular/cell biology, (physical/bio) chemistry, (bio)physics and optics. We develop cutting-edge (super-resolution) microscopy and analysis tools, establish new classes of fluorescence probes and apply them directly to address relevant questions in molecular and cell biology.
For more information: visit Grussmayer Lab website.
× - Jos Zwanikken, Delft
Physics of Nanostructures
- Paul Alkemade, Delft
The Kavli Nanolab houses the large fabrication tools for nanoscience and nanotechnology: a large clean room with growth and etching equipment and with photon, electron, and ion pattern writers. Here, researchers –students to senior– make devices in which they study e.g. electronic, optical, quantum-mechanical, magnetic properties of nanoscale objects or use them as artificial environments to interact with biological molecules or cells.
The Alkemade Lab is the part of the Kavli Nanolab that explores new concepts of nanofabrication technologies. The focus is on ultrahigh resolution fabrication with electron and ion beams: the finest pens, down to a single nanometer in size. Bachelor and master projects are often linked to the group’s development and research activities at this frontier of nanoscience and -technology.
For further infomation: https://www.tudelft.nl/en/faculty-of-applied-sciences/about-faculty/departments/quantum-nanoscience/kavli-nanolab-delft/people/alkemade-lab/
× - Gerrit Bauer, Delft
Theoretical physics of nanostructures: electronic, magnetic, thermodynamical, optical and mechanical properties.
For more information: https://www.tudelft.nl/tnw/over-faculteit/afdelingen/quantum-nanoscience/prof-dr-gerrit-bauer/
× - Carlo Beenakker, Leiden
The nanophysics group at the Lorentz Institute studies theoretically the quantum transport properties of nanostructured materials, in particular with regards to their potential for solid-state quantum information processing. We collaborate closely with the experimental nanophysics group at Delft University of Technology. Quantum transport of Dirac and Majorana fermions in graphene and in topological insulators is central to our current interests.
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For more information: http://www.lorentz.leidenuniv.nl/beenakker/ - Yaroslav Blanter, Delft
- Nanomagnonics and cavity
- Optomagnonics
- Nanomechanics
- Quantum transport
For more information: https://www.tudelft.nl/tnw/over-faculteit/afdelingen/quantum-nanoscience/prof-dr-yaroslav-blanter/
× - Andrea Caviglia, Delft
In our lab we use high-end thin film deposition technologies to create new quantum nanomaterials. We design and control the composition of each atomic layer of artificial crystalline structures with the aim of exploring the physics of new electron systems.
Our main focus is on a class of materials known as complex oxides. These display an amazing variety of different electronic properties such as magnetism and superconductivity at much higher temperatures than any other material. Such remarkable diversity is found in materials possessing a similar crystalline structure. This creates the opportunity to combine them in artificial crystals characterised by sharp interfaces, just as Lego bricks of different colours can be assembled in a single structure.
Our ultimate challenge is to design and produce new correlated phases of matter. We are driven by scientific curiosity but at the same time we are alert to the practical application of our research in energy conversion and electronics.
For more information: http://caviglialab.tudelft.nl/
× - Sonia Conesa Boj, Delft
The aim of my group will be to develop and apply innovative analysis techniques for the characterization of nanoscale materials based on Transmission Electron Microscopy (TEM) and related techniques. TEM methods allow imaging materials with atomic resolution, and provide unique insight for the understanding of the structural, chemical and electrical properties of novel materials, paving the way for their applications as building blocks of next-generation nanodevices. In particular, my group will use TEM methods to investigate the fascinating properties of low-dimensional nanomaterials, such as nanowires, and of recently discovered quantum materials, such as topological insulators and nitrogen vacancy centers in diamond. Most of these materials are rather new, and we are only now starting to unravel their true potentialities.
For more information: https://conesabojlab.tudelft.nl/
× - Frank Dirne, Delft
- Ronald Hanson, Delft
We exploit the remarkable properties of spins in diamond to study and engineer interactions between individual quantum systems in often very fundamental physics experiments, with the long-term goal of building a quantum computer and realizing a quantum internet. Our work is highly interdisciplinary, combining the fields of quantum optics, condensed matter physics, quantum information, nano-fabrication and quantum physics theory. Thanks to a number of exciting breakthroughs our systems currently operate at the cutting edge of quantum science, enabling exploration of open scientific questions as well as pushing the state of the art in quantum information processing.
For more information: https://qutech.nl/hanson-lab/
× - Kobus Kuipers, Delft
Kobus Kuipers is one of the pioneers in the field of nanophotonics. He is internationally recognized for developing techniques that probe the electric and magnetic field of light on the nanometer length scale and the femtosecond time scale. With these techniques he obtained novel insights in the fundamental properties of light in nanostructures.
Kuipers has strongly contributed to the development of the nanophotonics research field in the Netherlands. Together with Albert Polman, he founded the Center for Nanophotonics at AMOLF, and made it a leading center for nanophotonics research. Since November 2016 Prof. dr. Kuipers is head of the Quantum Nanoscience department in TU Delft, part of the Kavli Institute of Nanoscience Delft.
For further information: https://kuiperslab.tudelft.nl/pages/kuipers/
× - Sense Jan van der Molen, Leiden
In the Van der Molen lab, we investigate the properties of low-dimensional materials, with an enthusiastic scientific team. We focus on two types of quantum systems.
First, we investigate charge transport (conductance) through molecules. The latter can be seen as quasi-one dimensional quantum systems, with properties that can be tuned by chemical synthesis. We have a specific interest in functional molecules, e.g. photochromic switches and spin-crossover compounds. J. Phys.: Cond. Matter 22 (2010) 133001
Second, we study the electronic properties of and charge transport in quasi two-dimensional systems. The most famous of these is undoubtedly graphene, a carbon layer of exactly one atom thick. But there are many more, e.g. hexagonal BN, MoS2 etc. Remarkably, such layers can be stacked to create novel materials with properites that we may be able to tune! To reach that point one day, we are accurately studying the electronic interaction between different layers within such 'Van der Waals materials'. We have a unique way to do this, thanks to special low-energy electron microscope (LEEM), that we have adapted to our needs.
For more information: https://www.physics.leidenuniv.nl/vandermolen
× - Sander Otte, Delft
All existing technology makes use of the properties of various materials – be it electrical, magnetic or optical. These properties have their origins in the way atoms inside those materials interact. But how exactly they come about is not always easy to understand or predict. In our lab we explore the very beginnings of what makes a material. To this end we engineer and craft assemblies of tens, hundreds or even thousands of atoms using low temperature scanning tunneling microscopy, and investigate their collective characteristics as they emerge.
For more information: https://ottelab.tudelft.nl/
× - Jan van Ruitenbeek, Leiden
Single-molecule junctions
Our interest in single-molecule junctions has evolved logically from the invention of the Mechanically Controllable Break Junction (MCBJ) technique in our group, and the research on single-atom contacts that was made possible by it. We have focused initially on very simple molecules (H2, H2O, C6H6, etc) connected between Pt leads. Experiments at low-temperature permit detailed characterization of the junctions, for which we exploited the measurement of shot noise, and vibration mode spectroscopy in the differential conductance. More recently the work is continued in three directions:
1.Tree-terminal single-molecule junctions.
2. Shot noise
3. Low-temperature STM
For more information: https://www.universiteitleiden.nl/en/staffmembers/jan-van-ruitenbeek#tab-2
× - Gary Steele, Delft
The core of our research is focussed on using microwave photons trapped in superconducting circuits to probe and control mechanical resonators in the quantum regime.
For more information on who we are and the types of things we do: https://steelelab.tudelft.nl/
× - Peter Steeneken, Delft
We study the physics of nanodevices with the goal to apply them in the semiconductor industry. Miniaturization of device dimensions towards the nanoscale can offer clear advantages in terms of operation speed, device density and sensitivity. CMOS integration of nanomaterials is therefore expected to enable breakthroughs in computing, communication and sensing.
In particular we focus on the integration of 2D nanomaterials with CMOS in order to create novel electromechanical sensors. Since materials like graphene can be suspended as atomically thin membranes, they provide ultimate flexibility. This opens up the possibility to create sensors with unprecedented sensitivity.
http://steenekenlab.tudelft.nl/
× - Jos Thijssen, Delft
My research focuses mainly on the theory of single molecule charge trasport, mainly using nonequilibrium Green's function theory. In my group, we have implemented a NEGF module in the quantum chemistry software packages of SCM.
We have also worked on interaction with vibrational modes (Jos Seldenthuis) and on including Coulomb effects.
For more information:https://www.tudelft.nl/tnw/over-faculteit/afdelingen/quantum-nanoscience/thijssen-group/research/
× - Herre van der Zant, Delft
In our lab, we study different nanostructures such as molecules, 2D materials and biological matters. Particularly we are interested in the electronic characterization of these nanostructures for fundamental understandings and device applications. For example, we study the electronic transport in single molecules through mechanically-controlled break junctions (MCBJ) and electromigrated junctions, which allow us to explore the electronic properties of functional molecules and quantum effects at single-molecule level. We are always developing new techniques to aid us researching in novel device platforms such as graphene break junction, where we can mechanically strain and break graphene. We are a very diverse group, our research topics ranged from single-molecule characterization in solution, spin-injection in chiral molecules, graphene nano-ribbon, thermoelectricity, biological nanowires…etc. You can also find our past research topics in the publications section.
For more information: http://vanderzantlab.tudelft.nl/
× - Toeno van der Sar, Delft
We are a new lab that uses spins in diamond to explore condensed-matter systems, ranging from magnets to quantum devices. The magnetic fields generated by spins and currents provide a unique window into condensed-matter physics. We study these fields at the nanoscale using the excellent sensitivity and broad temperature operability of the nitrogen-vacancy (NV) sensor spin in diamond.
For more information: https://www.tudelft.nl/tnw/over-faculteit/afdelingen/quantum-nanoscience/van-der-sar-lab/
× - Roel Smit, Delft
“In august 2020 I joined the Casimir Researchschool. As Director of Studies of the Bachelor Programme for Applied Physics at Delft University of Technology my biggest responsibility is with education. After several years of teaching at an applied university, I find it very interesting to apply my knowledge and experience at Delft.
Although my attention is mainly focused on education, I am also going to play a role in the research of the department. How this is going to take shape has not yet been decided on.”
×
Quantum Matter and Functional Materials
- Jan Aarts, Leiden
Magnetic & Superconducting Materials
In my group (the Aarts lab) we combine or structure materials, mostly in thin film form, in such a way that the hybrid has different and novel properties or functionalities.
A good example is our work on combinations of superconductors and ferromagnets. It turns out to be possible to induce superconductivity in a ferromagnet over very long length scales using the mechanism of ‘odd-frequency s-wave triplet formation’.
Another research line involves complex oxides. We are currenty studying the question whether the electron gas which forms at the interface between the two band insulators can be made magnetic.
There are also several smaller projects which involve the fabrication of graphene for use in other hybrid structures, or work on particular superconducting properties of various materials.
The group has extensive facilities for thin film deposition (sputtering), for sub-micron structuring (electron beam patterning), for characterization (Xray, AFM), and for low-temperature measurements.
For more information: https://www.universiteitleiden.nl/en/staffmembers/jan-aarts#tab-2
× - Milan Allan, Leiden
We are a dynamic research group at the Leiden Institute of Physics. Our aim is to explore and understand quantum materials, including strange metals, high-temperature superconductors, and quantum critical electron matter.
To this end, we develop novel spectroscopic-imaging scanning tunneling microscopy (SI-STM) tools to visualize the relevant quantum mechanical degrees of freedom. We want to be able to build the perfect instruments to answer the scientific questions we deem most important.
For more information: http://www.allanlab.org/
× - Ekkes Brueck, Delft
The section FAME performs research on functional and structural materials aimed at practical applications. The focus is on the study of the relations between structure, dynamics and function at the atomic and nanoscale. For this we use neutrons, positrons, X-rays, NMR, muons, Mossbauer spectroscopy and first principles modeling, at both local (RID) and international facilities. FAME collaborates closely with NPM2.
For more information: https://www.tudelft.nl/tnw/over-faculteit/afdelingen/radiation-science-technology/research/research-groups/fundamental-aspects-of-materials-and-energy/
× - Vadim Cheianov, Leiden
- Peter Denteneer, Leiden
- Niels van Dijk, Delft
The section Fundamental Aspects of Materials and Energy, FAME, performs research on functional and structural materials aimed at practical applications. The focus is on the study of the relations between structure, dynamics and function at the atomic and nanoscale. For this we use neutrons, positrons, X-rays, NMR, muons, Mossbauer spectroscopy and first principles modeling, at both local (RID) and international facilities.
For more information: https://www.tudelft.nl/tnw/over-faculteit/afdelingen/radiation-science-technology/research/research-groups/fundamental-aspects-of-materials-and-energy/
× - Stephan Eijt, Delft
The section Fundamental Aspects of Materials and Energy, FAME, performs research on functional and structural materials aimed at practical applications. The focus is on the study of the relations between structure, dynamics and function at the atomic and nanoscale. For this we use neutrons, positrons, X-rays, NMR, muons, Mossbauer spectroscopy and first principles modeling, at both local (RID) and international facilities.
For more information: https://www.tudelft.nl/tnw/over-faculteit/afdelingen/radiation-science-technology/research/research-groups/fundamental-aspects-of-materials-and-energy/
× - Eliska Greplova, Delft
In September 2020, Eliška Greplová started her own group at QN called “Quantum Matter and AI”. More information about her research can be found here: https://www.eliskagreplova.com.
× - Teun Klapwijk, Delft
Scanning THz Impedance Microscopy for Quantum materials
In many new materials, such as ceramic superconductors, manganites (Lai et al, Science 329,190 (2010)), and strongly disordered superconductors (Sacépé et al, PRL 101,157006 (2008)) homogeneous atomic order goes together with very inhomogeneous electronic properties.
The challenge for experiments is to measure the local, nanoscale, lectrodynamic properties in materials. I am developing a new technique to determine these local variations of the electronic properties. The method is derived from the recent progress in astronomical instruments for the submillimeter (hundreds of GHz to THz) frequency band. This progress, to which I contributed extensively, was driven by the desire to study the universe, but with this technology and expertise in hand it is now possible to cross the disciplinary boundaries again. The new instrument will make it possible to determine the local (and possibly the frequency-dependent) electromagnetic properties, such as the dielectric constant and conductivity, for a range of materials. Contact: t.m.klapwijk@tudelft.nl (zie also http://www.cosmonanoscience.tudelft.nl)
× - Fokko Mulder, Delft
The focus of my research is the fundamentals as well as practical aspects of energy storage and conversion materials for renewable energy applications. The overall goal is to study materials and methods that can contribute to the large scale implementation of renewable energy storage, and with that can enable large scale introduction of varying renewable energy sources. The materials studied include hydrogen storage materials, battery materials and electrolytes. The fundamental aspects studied include the physical effects of nanostructuring, the reversibility of hydrogen and lithium storage materials, electrochemical reactions, and in general factors that enable efficient and durable functioning of the materials.
For more information: https://www.tudelft.nl/tnw/over-faculteit/afdelingen/chemical-engineering/scientific-staff/fokko-mulder/
× - Toeno van der Sar, Delft
We are a new lab that uses spins in diamond to explore condensed-matter systems, ranging from magnets to quantum devices. The magnetic fields generated by spins and currents provide a unique window into condensed-matter physics. We study these fields at the nanoscale using the excellent sensitivity and broad temperature operability of the nitrogen-vacancy (NV) sensor spin in diamond.
For more information: https://www.tudelft.nl/tnw/over-faculteit/afdelingen/quantum-nanoscience/van-der-sar-lab/ × - Frans Tichelaar, Delft
The National Centre for High Resolution Electron Microscopy
The department’s research is aimed at:
- The realization of in-situ measurements combining structural investigations with for example electrical measurement or a gas atmosphere at elevated temperature in the transmission electron microscope,
- In-situ modification of materials at the nano scale,
- The analysis and understanding of the relation between the properties of crystalline materials and their structure, composition and morphology,
- Energy filtered transmission electron microscopy allowing the joint investigation of atomic arrangement, composition and electronic structure with 0.1 eV energy resolution.
In addition, the department provides facilities and service for electron microscopy investigations.
× - Rudolf Tromp, Leiden